Research Paper Volume 8, Issue 4 pp 712—728

A robust neuromuscular system protects rat and human skeletal muscle from sarcopenia


Figure 1. Rat forelimb muscles are resistant to age-related skeletal muscle atrophy. (A-B) Hindlimb (A) or forelimb (B) skeletal muscles weight, normalized to body weight, isolated from 8, 18, 20, 22, or 24 month old male wistar rats. (C-D) Tibialis anterior (C) and biceps brachii (D) fiber cross-sectional area distribution measured from a laminin staining. Representative images for adult and sarcopenic conditions are shown. n=9-10 per group for muscle weights, n=4-5 per group for histology. For histology, >1000 fibers per section were analyzed. * p<0.05 ** p<0.01 *** p<0.001 with a one-way ANOVA test. Scale bars represent 100 μm.