Research Paper Volume 8, Issue 4 pp 712—728

A robust neuromuscular system protects rat and human skeletal muscle from sarcopenia


Figure 3. Neuromuscular transmission declines specifically with age in hindlimb but not forelimb muscles in rats. Compound muscle action potential (CMAP) was measured by electromyography in hindlimb (A) or forelimb (C) muscles of adult, early-sarcopenic or sarcopenic rats after stimulation of sciatic (A) and radial nerves (C). (B, D) Representative examples of CMAP from adult and sarcopenic gastrocnemius and triceps brachii muscles. For all graphs n=9-12 per group. * p<0.05 ** p<0.01 *** p<0.001 with a one-way ANOVA test.