Research Paper Volume 8, Issue 4 pp 712—728

A robust neuromuscular system protects rat and human skeletal muscle from sarcopenia


Figure 6. Transcriptional profiling of nerves in aged rats identifies specific molecular signatures associated with the severity of neuromuscular decline. (A) Venn diagram comparing the overlap of gene regulation with age between sciatic and radial nerves using a linear model. Genes were considered significantly regulated when the absolute fold change was > 2 and the adjusted p-value < 0.05 (FDR = 5%). (B) Gene Ontology enrichment analysis of genes responding differently to age in the two nerve types (interaction term in the 2 by 2-factorial design). (C) Gene expression level for key enzymes regulating cholesterol synthesis. (D) Gene expression level for neutrophic genes: BDNF, FGF5 and the neurotrophin receptor p75NTR. For all graphs n=8 per group. * p<0.05 ** p<0.01 *** p<0.001 with a one-way ANOVA test.