Research Paper Volume 8, Issue 4 pp 730—750

N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice

Figure 8. Epon embedded cross sections (3 μM) of the macula of the utricle stained with toluidine blue from a 9-month-old (A) +/+ mouse and a (B) dwg/dwg mouse. Numerous hair cells (HC) surrounded by large translucent afferent synapses decorated the vestibular hair cells in the sensory epithelium of +/+ mouse whereas many vestibular hair cells were missing and large vacuoles present in the vestibular epithelium of saccule of dwg/dwg mice. Epon embedded cross section (3 μM) of the crista of the ampulla stained with toluidine blue from a 9 month old (C) +/+ mouse and (D) dwg/dwg mouse. Numerous hair cells (HC) surround the translucent afferent synapses in the sensory epithelium in +/+ mouse whereas many HC were missing in the crista of dwg/dwg mice.