Editorial Volume 8, Issue 3 pp 423—424

Telomere length connects melanoma and glioma predispositions


Figure 1. The effect of telomere-lengthening variants on the risks of glioma and melanoma. Seven single nucleotide polymorphisms (SNPs) associated with inter-individual variation in leukocyte telomere length (LTL) were evaluated for their association with risks of glioma [5] and melanoma[6]. The x-axis plots the effect size of each SNP on glioma risk, while the y-axis plots the effect size of each SNP on melanoma risk. Effect sizes are displayed as Beta values from ancestry-adjusted logistic regression analyses. A positive correlation between a SNP's effect on glioma and its effect on melanoma was observed (r=0.56). Bubble sizes are proportional to the effect size of each SNP on LTL[2]. Beta values for glioma and melanoma are for each additional copy of the allele associated with longer LTL.