Letter to the Editor Volume 8, Issue 4 pp 565—566

Oncogenic epigenetic control


Figure 1. Dynamics of H3K4ac epigenetic modifications in cell lines representative of breast/breast cancer subtypes. The central image represents the epithelial layers in a human breast duct and the cell lines used in the study discussed here. MCF10A is a normal-like basal epithelial–derived cell line; MCF7 represents the ER+/PR+ luminal-cell subtype, correlative with a relatively favorable prognosis; and MDA-MB-231 is representative of the ER−/PR−/Her2− metastatic basal cell subtype, correlative with a less favorable prognosis. The upper network shows changes in H3K4ac between MCF10A and MCF7 for genes involved in estrogen-response. The lower network compares H3K4ac between MCF10A and MDA-MB-231 for genes involved in the epithelial to mesenchymal transition. Differences in enrichment between cell lines as indicated by color and size of nodes.