Research Paper Volume 8, Issue 5 pp 1049—1060

Ischemic stroke induces gut permeability and enhances bacterial translocation leading to sepsis in aged mice

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Figure 4. The effects of age and stroke on peripheral lymphocytes 72 hours after 90 minute MCAO. (A) There was an effect of stroke (F(1,46)=p<0.0001) on the ratio of circulating lymphocytes to myeloid cells, a measure of lymphopenia, as analyzed by 2-way ANOVA (n=10-15/group). This ratio was significantly reduced in young (p<0.05) and aged (p<0.0001) mice following stroke. (B) There was a significant effect of stroke (F(1,14)=p<0.005, n=3-6/group) but not age on the proportion of circulating CD69+ CD4+ T cells as analyzed by 2-way ANOVA. (C) The proportion of circulating CD8+ T cells expressing CD69 was affected by both stroke (F(1,14)=p=0.05) and age (F(1,14)=p<0.05) via 2-way ANOVA (n=3-6/group). Values are expressed as mean ± SEM. *, p≤0.05; ***, p<0.001.