Research Paper Volume 8, Issue 7 pp 1316—1327

Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses


Figure 3. Circuits that mediate paracrine interactions between senescent cells and surrounding environment. According to experimental results and literature data we propose: MMP2 and TIMP2 may play a key role in pathways regulating the effect of senescent secretomes on cancer cells; IGFBP3 and PAI-1 are part of the paracrine circuit that induces senescence in neighboring cells; and PRDX6, ERP46, PARK7, Cathepsin D, and MVP could be part of the common circuit that allows senescent cell survival following stress.