Research Paper Volume 8, Issue 5 pp 1064—1078

Figure 7. SIRT6 overexpression suppressed the expression of multiple atherosclerosis-related genes in human endothelial cells. (A-B) Molecular Function Gene Ontology (GO) and pathway enrichment analysis of the 198 genes that were downregulated by SIRT6 overexpression, determined by RNA-seq, n=2/each condition. The lists of genes were analyzed using Enrichr database, based on the combined score ranking. The brighter the color, the more significantly enriched GO term and pathway displayed. Please refer to Table S4 and S5 for complete list of gene change. (C) DAVID functional annotation clustering analysis of genes downregulated by SIRT6 overexpression. (D) Selected atherosclerosis-related genes downregulated by SIRT6 overexpression (OE) detected by RNA-seq analysis.