Editorial Volume 8, Issue 7 pp 1292—1293

Figure. Predictive model for how changes in the ARNT isoform ratio impacts basal AHR activity and cell proliferation. Upper Panel: Schematic representation of AHR and the ARNT isoforms. Lower Panel: (A) Normal lymphocytes exhibit equal levels of ARNT isoform 1 and 3, providing basal AHR activity that keeps the cells at homeostasis. (B) Lymphoid malignancies, and possibly activated normal lymphocytes, have high isoform 1:3 ratios that keep basal AHR activity low and allow for cell proliferation. (C) Depicts high basal AHR activity after lowering of isoform 1:3 ratios. A=AHR; 1=ARNT isoform 1; 3=ARNT isoform 3; Co-AC=Transcriptional co-activator; DRE=Dioxin response element.