Research Paper Volume 9, Issue 1 pp 98—113

Aging enhances liver fibrotic response in mice through hampering extracellular matrix remodeling

Figure 2. Gene expression of matrix remodeling enzymes in young and old livers. Hepatic gene expression of Mmp2, Mmp3, Mmp8, Mmp9, Mmp13, Mmp14, Timp1, Timp2 and Cxcl9 in control and CCl4-treated young and old mice (Mean ± SEM) (n=6/group). Statistical analysis was performed by two-way ANOVA for repeated measures (boxes) followed by Bonferroni’s post-hoc correction. **P<0.01; ***P<0.001 for differences between age groups.