Research Paper Volume 8, Issue 12 pp 3430—3449

Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex


Figure 6. Higher rates of neuronal activity in layer II/III of PrLC in AAV-hAPP-SLA injected mice. (A) Representative spontaneous Ca2+ transients of sham-operated mice and hAPP mice and corresponding raster plots 1 and 6 mpi. (B) Population averaged cumulative plot of the distribution of spontaneous transients/min. (C) Median frequency of spontaneous calcium transients/min of the different mouse groups. (D) Median transient durations. (E-H) Kernel estimation for the different mouse groups. The kernel (model) is obtained from the fitting of an alpha function on the mean unitary calcium transient (crosses). In light gray, individual unitary calcium transients used to compute the mean for sham-operated and hAPP mice at 1 and 6 mpi of the vector. (I) Population averaged cumulative histograms of the distribution of spontaneous spikes/min. (J) Median frequency of spontaneous calcium spikes/min of the different mouse groups (n = 4 animals for each group). Kruskal-Wallis test for all comparisons. (*P<0.05, **P<0.01 and ***P<0.001)