Figure 1. Relationship between glucose homeostasis parameters and age. Glucose metabolism parameters were evaluated in young (grey symbols, range: 2.4 to 3.5 years old) and middle-aged (black symbols, range: 4.1 to 6.1 years old) mouse lemurs. (A) Spearman correlation of fasting blood glucose levels and age. (B) Spearman correlation of fasting blood insulin levels and age. (C) Oral glucose tolerance test (OGTT): Blood glucose was measured 0, 30, 60 and 120 min after oral administration of 1.75g glucose/g of body mass (Two-way ANOVA: age p<0.01, time p<0.001, time x age p=0.11). (D) Spearman correlation of area under curve of OGTT and age.