Editorial Volume 8, Issue 12 pp 3155—3156

Figure 1. MUC1-C→NF-κB signaling integrates EMT and DNA methylation-induced changes in gene expression. MUC1-C activates the inflammatory TAK1→IKK→NF-κB p65 pathway. MUC1-C also binds directly to NF-κB p65, increases occupancy of MUC1-C/NF-κB p65 complexes on the ZEB1 promoter, induces ZEB1 expression, and drives EMT by ZEB1-mediated mechanisms. Additionally, MUC1-C increases MUC1-C/NF-κB p65 occupancy on the DNMT1/3b promoters, induces DNMT1/3b expression, and alters global and gene-specific DNA methylation patterns. In this way, MUC1-C→NF-κB p65 signaling plays a role in integrating EMT with epigenetic changes in gene expression and the repression of TSGs.