Figure 3. VHT overexpression of ΔFosB increases insulin sensitivity in the periphery. Mice were stereotaxically injected into VHT with AAV-ΔFosB or AAV-GFP and insulin response was assessed 8 weeks post-surgically (n=8). (A) Body weight (B) Abdominal epididymal fat pad weight (C) ITT, data are presented as percentage of initial blood glucose concentration (D) HOMA-IR (E) Western blotting of Akt phospholylation in skeletal muscle and brown fat (BAT). Data are presented as mean ± SEM. *p<0.05, p<0.01.