Research Paper Volume 9, Issue 2 pp 353—369

Hypothalamic ΔFosB prevents age-related metabolic decline and functions via SNS

Figure 4. VHT-overexpression of ΔFosB-mediated amelioration of insulin sensitivity precedes reduction in visceral adiposity. Mice were stereotaxically injected into VHT with AAV-ΔFosB or AAV-GFP and insulin response was assessed 2-3 weeks post-surgically (n=5). (A) Body weight (B) Abdominal epididymal fat pad weight (C) GTT glucose (D) GTT insulin (E) ITT glucose (F) HOMA-IR. (E) Akt phospholylation in skeletal muscle after insulin treatment. Data are mean ± SEM. *p<0.05, p<0.01.