Figure 7. The SNS blockade diminishes the VHT ΔFosB-mediated improvement in glucose tolerance and insulin sensitivity. Mice were stereotaxically injected into VHT with AAV-∆FosB or AAV-GFP, and then were treated biweekly (every two weeks) with SNS blocker 6-OHDA for a total of 3 injections. Metabolic assessment was performed 6-7 weeks post-surgically (n=4-5) (A) GTT glucose (B) GTT insulin (C) ITT glucose. Data are expressed as mean ± SEM. Levels not connected by same letter are significantly different (p<0.05).