Research Paper Volume 9, Issue 2 pp 353—369

Hypothalamic ΔFosB prevents age-related metabolic decline and functions via SNS

Figure 8. ΔFosB overexpressed in VHT regulates insulin secretion via α-, but not β-adrenergic receptor in aged mice. Mice were stereotaxically injected into VHT with AAV-∆FosB or AAV-GFP and treated 38-40 weeks post-surgically with either α-AR blocker phentolamine (PHE) or β-AR blocker propranolol (PRO) (n=3-4). (A) Urinary epinephrine and (B) norepinephrine in untreated aged mice. (C) GTT glucose of PHE-treated groups (D) GTT glucose of PRO-treated groups (E) GTT insulin of PHE-treated groups (F) GTT insulin of PRO-treated groups (G) ITT glucose of PHE-treated groups (H) ITT glucose of PRO-treated groups. Data are expressed as mean ±SEM. *p<0.05, **p<0.01.