Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal osteopenic women following a one-year double-blind RCT and on osteoblast-osteoclast co-cultures

Sifat Maria; Mark H. Swanson; Larry T. Enderby; Frank D’Amico; Brianna Enderby; Rebekah M. Samsonraj; Amel Dudakovic; Andre J. van Wijnen; Paula A. Witt-Enderby

doi:doi:10.18632/aging.101158

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Research Paper Volume 9, Issue 1 pp 256—285

Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal osteopenic women following a one-year double-blind RCT and on osteoblast-osteoclast co-cultures

Figure 5. Treatment effects on participants' sleep quality, mood, GI upset and general aches/pains in placebo and MSDK groups. (A) Total diary comments made by the participants in each group throughout the study were stratified into four categories: sleep, mood, GI upset and general aches/pains, as illustrated by the four segments in the pie diagram. Each category was sub-stratified as positive (pink), neutral (yellow) and negative (green) comments. Each portion represents the percent of total comments made under each category.