Research Paper Volume 9, Issue 1 pp 256—285

Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal osteopenic women following a one-year double-blind RCT and on osteoblast-osteoclast co-cultures

Figure 9A-C. Effect of MSDK on MAPKs, ERK1/2 and ERK5. After 21 days of MSDK exposure, western blot was performed to determine (A) ERK1/2 expression of osteoblasts grown as transwell co-cultures, (B) ERK1/2 expression of osteoblasts and osteoclasts grown as layered co-cultures, (C) ERK5 expression of osteoblasts grown as transwell co-cultures.