Figure 5A. Models of aging-related changes in TCA cycle and pyrimidine metabolism. (A) A summary of the biochemical pathway of TCA cycle metabolism alerted during aging, and glp-1 against WT. In summary, with aging, accumulation of the TCA cycle intermediates such as citrate and malate suggests increased TCA cycle metabolism. Furthermore, in the long-lived glp-1 mutants, the levels of TCA cycle intermediates decreased at stage of the young adults and 10-day adults compared with WT.