Figure 5B. Models of aging-related changes in TCA cycle and pyrimidine metabolism. (B) The representative schematic of pyrimidine metabolism. The pyrimidine metabolism decreased during aging. And glp-1 mutants showed the increased levels of pyrimidine intermediates at stage of the young adults and 10-day-old worms compared with WT. Values are presented as box-and-whisker plots. *p<0.05; **p<0.01; ***p<0.001.