Research Paper Volume 9, Issue 2 pp 508—523

Resveratrol fuels HER2 and ERα-positive breast cancer behaving as proteasome inhibitor

Figure 1. Resveratrol fuels mammary tumor formation in a luminal B breast cancer in vivo model. (a) Schematic representation of the experimental workflow used for the treatment of Δ16HER2 mice with vehicle or resveratrol. (b) Kaplan-Meier disease-free survival plot for vehicle- (n= 9) and resveratrol-treated (n= 9) Δ16HER2 mice. **p ≤ 0.01, Log Rank test. (c) Tumor multiplicity in resveratrol-treated vs control mice; the number of palpable mammary tumors per mouse is represented as mean ± SD. Statistical significance was assessed by two-way ANOVA test. (d) Left panel: Representative Hematoxyilin-Eosin (H&E) and PCNA stained sections of tumors from resveratrol and vehicle treated mice. Magnification 400 X. Right panel: Quantification of PCNA staining in tumors from resveratrol and vehicle treated mice. Data are expressed as mean ± SEM. *p < 0.05; unpaired two-tailed student t test.