Research Paper Volume 9, Issue 2 pp 556—572

Characterization of the influence of age on GABAA and glutamatergic mediated functions in the dorsolateral prefrontal cortex using paired-pulse TMS-EEG

Figure 1. Modulation of TEPs by the DLPFC-SICI paradigm in older adults. (A) The graph depicts TEP traces averaged across the older adults for subthreshold TMS (black dot line: CS), unconditioned TMS (red line: TS) and conditioned TMS (blue line: SICI; ISI = 2ms) at the left frontal ROI. (B) The illustration shows the EEG topographical plots for conditions of TS alone, SICI, and the difference between TS and SICI obtained from the DLPFC-SICI experiment. Each vertical column depicts the TEP topoplots for P30, N45, P60, N100, and P180 component from left to right. (C) The bar graph shows modulatory effects of the DLPFC-SICI on TEPs in the older adults. The ANOVA and post-hoc analyses revealed that there are significant modulations (p < 0.05) in P60, N100, and P180 TEPs with the DLPFC-SICI paradigm. (D) The bar graph showing cross-sectional comparisons between younger and older adults in the DLPFC-SICI paradigm. The older adults show a significant facilitation of amplitude of N100 TEP than the younger adults (p < 0.05).