Research Paper Volume 9, Issue 3 pp 665—686

Figure 2. The number of centrosomes per cell varies with dose and age. Centrosome aberrations were further classified into cells containing 3 centrosomes (3P= 3 pericentrin foci) and those that had 4 or more (≥4P pericentrin foci). The fraction of cells with 3P and >4P were graphed relative to control. Roughly equitoxic doses of Cs and Ti were used for exposures (LD-CS = 0.12 Gy; HD-CS = 0.8 Gy; LD-Ti = 0.05 Gy; HD-Ti = 0.5 Gy). The dose effect on the change in 3P (A) and ≥4P (B) populations relative to control is shown. Wilcox test was used to determine statistical significance, *=p<0.05. The normalized proportion of aberrant cells with either 3P (C) or >4P (D) was plotted as a function of age. Regression lines analyzing the trends as a function of age were fitted to these data.