Research Paper Volume 9, Issue 3 pp 706—740

Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption

Figure 3. Development of idiosyncratic parathymic lobes in GIT2KO mice. Large parathymic lobes (PTLs) were consistently observed in 12 month old GIT2KO mice only (A: 1-thymus, 2-PTL). Total cell count data measured in WT and GIT2KO inguinal and mesenteric lymph nodes (ILN and MLN respectively), thymus and PTLs (GIT2KO only) (B). (C) PTLs express significantly lower Troma-I expression compared to WT or GIT2KO thymus (C). PTLs also demonstrate significantly-distinct patterns (compared to WT and GIT2KO thymus, ILN and MLN) of total counts for Lin- (D), ETP (E), DN2 (F) and DN3 (G) T cell precursors, as well as for CD8+ (H) and CD4+ (I) cells. All values indicated are mean ± SEM. For histograms WT data are represented by solid black objects, with GIT2KO data represented by lined objects. Months of age is abbreviated to m.o. *p<0.05, **p<0.01, ***p<0.001.