Figure 1. Cerebral substratum of episodic memory decline. (A) Transversal VBM analysis: grey matter volumes at baseline and memory decline. (B) Longitudinal VBM analysis: grey matter annual rates of atrophy and memory decline. Each model was adjusted for age, sex, level of education, APOE4 allele carrier status and total intracranial volume (except for longitudinal VBM analysis). Clusters presenting statistically significant associations (q<0.05, topological cluster FDR corrected) with variance of the memory decline are overlaid on a spatially normalized TI image of one subject of the sample. Coordinates are given in millimeters the MNI space. R = right side.