Research Paper Volume 9, Issue 3 pp 964—985

APOE ε4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer’s Disease

Figure 1. Ratios of AA to DHA and individual PL species stratified by diagnosis and the APOE ε4 carrier status. Mean ± SE (ε4-non carriers = 119 control and 13 MCI/AD; ε4 carrier = 53 controls and MCI/AD = 10). (A) There was an interaction between MCI/AD diagnosis and ε4 allele for PC (F = 10.81, p = 0.001), PE (F = 4.95, p = 0.027), PI (F = 9.13, p = 0.003) and LPC (F = 15.05, p < 0.001). Subjects with the ε4 allele who later converted to MCI/AD had higher ratios of AA to DHA within PC, LPC, PI and PE relative to ε4 controls and ε4 non-carriers. (B) Individual AA and DHA species which significantly contributed to the imbalance in AA to DHA ratios among ε4 carries with MCI/AD compared to other groups include ePC(36:4), ePC(40:4), PC(40:6), PE(38:4), PE(40:6), PE(40:8) and LPC(20:4). *p < 0.05 for post-hoc analyses.