Research Paper Volume 9, Issue 3 pp 964—985

APOE ε4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer’s Disease

Figure 2. Arachidonic acid and DHA containing PL species along with ε4 carrier status and Aβ have high accuracy for predicting MCI/AD diagnosis. Pilot ROC analyses were performed using the Cox-regression model consisting of a panel of PL that contained AA and DHA which included PE(36:4), PE(38:6), ePE(40:6), PE(40:6), LPC(20:4), LPC(22:6), ePC(36;4), ePC(40:4), ePC(40:6), PC(36:4), PC(38:4), PC(38:5), PC(40:4), PC(40:6), and PC(40:7). An AUC of 91% towards the diagnosis of MCI/AD was observed for this PL panel, ε4 and Aβ42/Aβ40 ratios. PL species alone provide an AUC of 88%. The APOE and ε4 together provided an AUC of 71%.