Research Paper Volume 9, Issue 3 pp 986—998

Mouse mitochondrial lipid composition is defined by age in brain and muscle

Figure 1. Mitochondrial lipid composition differs between tissue types and changes with age. (A) Orthogonal partial least square-discriminant analysis (OPLS-DA) of lipids found in the mitochondria of murine brain and skeletal muscle. Separation across the x-axis is according to tissue type. Along the y-axis separation delineates age. There are clear lipid compositional alterations between the mitochondria isolated from the two tissue types and with differences in age of the tissue. (B) OPLS-DA of lipid composition of murine brain mitochondria aged 4-11 weeks (pink) (n=10) and 78 weeks (red) (n=10). (C) OPLS-DA of the lipid composition of murine muscle mitochondria aged 4-11 weeks (yellow) (n=9) and 78 weeks (blue) (n=10).