Priority Research Paper Volume 9, Issue 3 pp 627—649

Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis

Figure 1. Survival and age-dependent dynamics of body weights in WT and Fus1 KO mice. (A) Survival curves for WT (n = 30) and Fus1 KO (n = 54) mice from 8 to 18 months of age. (B) Age-dependent changes in body weights of WT and Fus1 KO mice. *p-value ≤ 0.05; **p-value ≤ 0.005; ***p-value ≤ 0.0005 (Student’s t-test, 2-sided unpaired). Number of mice used in the analysis: 2 m.o. males, n = 11-12/group; 2 m.o. females, n = 15-18/group; 4-5 m.o. males, n = 17-18/group; 4-5 m.o. females, n = 8/group; 11- 15 m.o. males, n = 10/group; 11- 15 m.o. females, n = 9-13/group. Data expressed as mean ± SEM.