**Figure 1.** **Survival and age-dependent dynamics of body weights in WT and Fus1 KO mice.** (**A**) Survival curves for WT (*n* = 30) and Fus1 KO (*n* = 54) mice from 8 to 18 months of age. (**B**) Age-dependent changes in body weights of WT and Fus1 KO mice. **p*-value ≤ 0.05; ***p*-value ≤ 0.005; ****p*-value ≤ 0.0005 (Student’s *t*-test, 2-sided unpaired). Number of mice used in the analysis: 2 m.o. males, *n* = 11-12/group; 2 m.o. females, *n* = 15-18/group; 4-5 m.o. males, *n* = 17-18/group; 4-5 m.o. females, *n* = 8/group; 11- 15 m.o. males, *n* = 10/group; 11- 15 m.o. females, *n* = 9-13/group. Data expressed as mean ± SEM.