Research Paper Volume 9, Issue 4 pp 1219—1232

The differential spatiotemporal expression pattern of shelterin genes throughout lifespan

Figure 3. TRF2 expression remains high in the brain during adulthood. Representative photomicrographs of TRF2 immunostaining for the brain, heart, liver, and kidney (3,3' diaminobenzidine (DAB) substrate, brown, hematoxylin counterstaining) at different stages after birth. Note the persistent high expression of TRF2 in neurons of the brain (see also Supplementary Figure S1), the specific expression in subepicardial endothelial cells of the heart, and glomerular podocytes and juxta-glomerular cells of the kidney (arrows). Scale bars indicate 50µm.