Figure 4. Shelterin genes are differentially expressed during zebrafish life span. Quantitative RT-qPCRs for Shelterin components TRF1, TRF2 (TERFA), RAP1, TPP1, TIN2 and POT1 in zebrafish’s brain, heart, liver, intestine, muscle, gill, tail and ovary at different time-points of life span from 3 month to 36 month (n=6 each). Significance was tested between 3 month and 36 month. Data are mean ± SEM. *p<0.05, **p<0.01, ***p<0.001.