Research Paper Volume 9, Issue 4 pp 1233—1247

Aspirin inhibits the SHH/GLI1 signaling pathway and sensitizes malignant glioma cells to temozolomide therapy

Figure 7. Verification of aspirin sensitizing TMZ treatment through SHH/GLI1 Signaling in vivo. (A) Representative luminescence imaging and mean Fluc activity values of different treatment groups every week. (B) The subcutaneous U87 xenografts tissue were removed and subjected to Western blot analysis of GLI1, p-p65, p65, γH2AX, p-ATM and ATM. GAPDH was used as an internal control.