Research Paper Volume 9, Issue 4 pp 1269—1279

Protective effect of calretinin on testicular Leydig cells via the inhibition of apoptosis

Figure 5. Calretinin plays multiple protective roles in Leydig cells. Calretinin increases the cell viability and proliferation of Leydig cells possibly via the activation of the ERK1/2 and AKT pathways, and suppresses cell apoptosis possibly via the inhibition of the mitochondrial-related apoptotic pathway.