Research Paper Volume 9, Issue 4 pp 1307—1325

Paradoxical aging in HIV: immune senescence of B Cells is most prominent in young age

Figure 2. Spontaneous H1N1-specific ASCs at T1 in HIV (Black) and HC (Grey). (A) Mean ±SEM of H1N1 specific spontaneous ASC was assessed by ELISpot using PBMC 7 days after vaccination without any pre-activation. Mann-Whitney test was performed; *, Statistical significance at p <0.05. (B) H1N1 specific spontaneous ASC assessed in 60 Healthy controls (Left) and 64 HIV infected individuals (Right). ELISpot values are expressed as log2 scale. Age groups depicted as squares (young, <40 years), triangles (middle, 40-59 years) and circles (old, ≥60 years). Spearman correlation was performed.