Research Paper Volume 9, Issue 4 pp 1307—1325

Paradoxical aging in HIV: immune senescence of B Cells is most prominent in young age

Figure 8. PDL1+ B cells are related to immune aging and exhaustion of B cells. Frequencies of PDL1+ B cells at T0 were correlated with (A, B) frequencies of double negative B cells; (C, D) frequencies of exhausted B cells (DN/FcRL4+) and (E, F) with frequencies of exhausted T cells (CD4/PD1+) in 60 healthy controls (Left, Grey) and 64 HIV infected individuals (Right, Black). Age groups are depicted as squares (young, <40 years), triangles (middle, 40-59 years) and circles (old, ≥60 years). Spearman correlation was performed in all the correlation tests.