Research Paper Volume 9, Issue 7 pp 1660—1676

Chemo brain or tumor brain - that is the question: the presence of extracranial tumors profoundly affects molecular processes in the prefrontal cortex of TumorGraft mice

Figure 2. Oxidative DNA damage in PFC tissues of intact and TNBC and PR+BC-bearing TumorGraft mice. (A) Levels of 8-oxo-7-hydrodeoxyguanosine (8-oxodG) in genomic DNA isolated from PFC tissues (mean ± SD, n=3 for INTACT and PR+BC mice; n=4 for TNBC mice). (B) Western immunoblotting analysis of the base excision repair protein OGG1; data are shown as relative units/percent change of control. Due to protein size differences and scarcity of tissue, membranes were re-used several times. * - significantly different from control mice, p<0.05, Student's t-test.