Research Paper Volume 9, Issue 7 pp 1660—1676

Chemo brain or tumor brain - that is the question: the presence of extracranial tumors profoundly affects molecular processes in the prefrontal cortex of TumorGraft mice

Figure 6. Levels of DNA methyltransferases DNMT1 and DNMT3a, methyl-CpG binding protein MeCP2, and oxidative damage repair protein OGG1, in in the PFC tissues of intact and TNBC and PR+BC-bearing chemotherapy treated and untreated TumorGraft mice. (A) DNA methyltransferases and MeCP2 protein; (B) OGG1 protein. Data are shown as relative units/percent change OF control. Data from chemotherapy-treated animals are shown along with intact controls and tumor-bearing untreated animals (also see Fig. 2B and 4). Due to protein size differences and scarcity of tissue, membranes were re-used several times. Significantly different from control mice -* p<0.05, # p<0.10, Student's t-test.