Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

James A. McCubrey; Kvin Lertpiriyapong; Linda S. Steelman; Steve L. Abrams; Li V. Yang; Ramiro M. Murata; Pedro L. Rosalen; Aurora Scalisi; Luca M. Neri; Lucio Cocco; Stefano Ratti; Alberto M. Martelli; Piotr Laidler; Joanna Dulińska-Litewka; Dariusz Rakus; Agnieszka Gizak; Paolo Lombardi; Ferdinando Nicoletti; Saverio Candido; Massimo Libra; Giuseppe Montalto; Melchiorre Cervello

doi:doi:10.18632/aging.101250

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Review Volume 9, Issue 6 pp 1477—1536

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

Figure 9. Overview of effects of curcumin on HIF-1alpha, miRs and metastasis. An overview of the effects of CUR on pathways involving migration, invasion and metastatic pathways are indicated. Red arrows indicate induction of an event; black closed arrows indicate suppression of an event.