Figure 2. The 4 different groups were classified by 88-miRNA signature in discovery and validation sets. Fisher discriminant analysis (Stepwise discriminant method) of Health control (HC), chronic hepatitis B (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC) subjects was performed to establish a 88-miRNA signature in the discovery set. With the 88-miRNA signature, HC, CHB, LC and HCC groups were classified and presented with classification plot (A), classification table (B), and classification sketch (C) in the discovery set. (D) The HC, CHB, LC and HCC groups were classified by the signature in validation set and presented with classification sketch.