Figure 4. circRNA_100269-miR-630 axis mediated proliferation of GC cell lines. (A) Endogenous circRNA_100269 expression in serial GC cell lines. (B) MiR-630 decreased by circRNA_100269 overexpression. (C) circRNA_100269 overexpression inhibits cell growth. (D) miR-630 can interrupt the cell growth inhibition function of circRNA_100269. (E) circRNA_100269 overexpression inhibits cell colony formation. (F) miR-630 can interrupt the inhibition function of cell colony formation of circRNA_100269. Error bars represent the mean of three separate determinations ± standard deviation (SD). Asterisk indicates statistically significant changes: * (P < 0.05), ** (P < 0.01).