Research Paper Volume 9, Issue 6 pp 1607—1622

Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory

Figure 2. Graphs show mean ± s.e.m. *** indicates a significant relationship between the considered CS GAGs and time by One Way Anova, p >0.001.** indicates a significant relationship between the considered ratio and time by Kruskal-Wallis test, p =0.002.B1, ECM fraction; B4, PNNs fraction; B1+B2+B3+B4, sum of GAGs from the four fractions of each brain; 3m, 3-month-old brains; 6m, 6-month-old brains; 12m, 12-month-old brains; 18m, 18-month-old brains; C4S, Chondroitin-4-sulfate; C6S, Chondroitin-6-sulfate; C0S, Chondroitin non-sulfated; HA, hyaluronic acid.