Research Paper Volume 9, Issue 6 pp 1607—1622

Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory

Figure 5. Graphs show mean ± s.e.m. Asterisks indicate a significant relationship between average longest neurite and type of GAGs extract used for plating. One Way Anova and Dunnett post-hoc comparisons:***p >0.001, **p =0.002.B1, ECM fraction; B4, PNNs fraction; 3m, 3-month-old brains; 6m, 6-month-old brains; 12m, 12-month-old brains; 18m, 18-month-old brains; C4S, Chondroitin-4-sulfate; C6S, Chondroitin-6-sulfate; lam, laminin; chABC, chondroitinase ABC. Scale bar: 100 µm.