Research Paper Volume 9, Issue 7 pp 1770—1824

The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome

Figure 11. Association between physiological/behavior data and expression levels of genes involved in substrate metabolism. Previously measured leptin and insulin levels, food anticipatory activity (FAA), body temperature (body T) and basal metabolic rate (BMR) [15,16,18,21] for each individual mouse were correlated with the normalized counts of genes involved in electron transport chain, gluconeogenesis, glycolysis and tricarboxylic acid (TCA) cycle. Purple indicates a negative correlation between genes and the measured physiological/behavior data while green indicates a positive correlation.