Research Paper Volume 9, Issue 7 pp 1770—1824

The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome

Figure 14. Integrated overview of the different theories of ageing affected by graded calorie restriction (CR). Red indicates a positive correlation with increasing CR while blue indicates a negative correlation. Grey indicates no linear changes with the increase in CR level. Genes or processes biologically related are grouped together indicated by a yellow box including the insulin/insulin like growth factor (IGF-1) signaling pathway, mechanistic target of rapamycin (mTOR) pathway, fuel utilization and autophagy.