Editorial Volume 9, Issue 9 pp 1945—1946

AURKA inhibition mimics BRCAness

Figure 1. AURKA Inhibition Induces BRCAness and Promotes NHEJ DNA Repair. PARP inhibitors (rucaparib, olaparib, niraparib) block DNA SSB repair. AURAK inhibitors (alisertib) blocks BRCA function and promotes error prone NHEJ DNA repair of DNA double strand breaks.