Research Paper Volume 9, Issue 10 pp 2098—2116

A new mutation-independent approach to cancer therapy: Inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis

Figure 13. The “Proteomics-to-Genomics (PTG)” approach for the in silico validation of new biomarkers and novel drug targets. In this flow-diagram, proteomics data from a cellular model is directly used to interrogate existing genomics data (transcriptional profiling) from clinical samples, which are linked to follow-up data. This approach directly allows for the in silico validation of i) the prognostic value (of a given candidate biomarker) and ii) helps to generate new targets for drug discovery, by directly demonstrating their clinical relevance.