Research Paper Volume 9, Issue 10 pp 2098—2116

A new mutation-independent approach to cancer therapy: Inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis

Figure 2. MYC-RAS co-operativity augments mammosphere formation. Note that stable transduction with H-Ras (G12V) alone has no effect on mammosphere formation. In contrast, transduction with c-Myc increases mammosphere formation by ~2.3-fold. Finally, co-transduction with c-Myc and H-Ras (G12V) synergistically increases mammosphere formation by ~3.15-fold, as compared to vector alone controls. Therefore, MYC-RAS co-operativity augments “stemness” in cancer cells.