Research Paper Volume 9, Issue 10 pp 2098—2116

A new mutation-independent approach to cancer therapy: Inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis

Figure 3. MYC-RAS co-operativity increases mitochondrial respiration. Oxygen consumption rate (OCR) was measured in MCF7 cell lines, using the Seahorse XFe96 metabolic flux analyzer. Both (A) OCR metabolic tracings and (B) Bar graphs are shown. Note that c-Myc and c-Myc plus H-Ras (G12V) increase mitochondrial respiration rates.